Comprehensive anti-gang initiatives combine enforcement, prevention, and reentry efforts to target gang-related gun violence in high-crime neighborhoods. Sites that implement this approach to tailor the program to their communities’ strengths and areas of need. Enforcement efforts include increased federal, state, and local prosecution; prosecution screening; and hot spots policing. Prevention and intervention efforts include skill building, education, outreach, school-based prevention, and substance use treatment. Reentry efforts include outreach and community-based services for individuals reentering the community following incarceration.